A few selected frames from a 4-minute animation that explores the pathophysiology of sickle cell disease and the progressive, tissue-damaging effects of chronic hemolysis and anemia.
Click on the image for full size and additional visuals.
Our assignment: visually depict several key critical aspects of the SCD story, such as hemoglobin S (HbS) polymerization, red blood cell sickling and tethering, vaso-occlusion, and chronic hemolysis.
Sickled red blood cells promote inflammation, obstruct the vasculature, injure the endothelium, and may lead to ischemic damage in vital organs. SCD is one of the most common inherited diseases worldwide.
Click link below to view related segment from 4-minute animation.
