Sequence offering insight into the science of tardive dyskinesia, a neurological syndrome caused by the long-term use of neuroleptic drugs.
When dopamine receptors are blocked, new hypersensitive dopamine receptors rise up from the postsynaptic membrane. As a result, the once-rejected dopamine binds to these new receptors and leads to excessive signaling — which impacts motor areas of the brain and causes repetitive, involuntary movements.
