Segment from 5-minute mechanism of action animation.
This sequence explores a hallmark and pathophysiological feature of Alzheimer’s disease: toxic amyloid beta aggregates (Aβ) that accumulate into plaques (neurofibrillary tangles) near neurons in the brain.
A challenge for this sequence was to show the assembly of these naturally occurring peptides – oligomers, fibrils, and plaques – all in one continuous shot.
In addition, we show how over time, extracellular amyloid beta aggregates, including oligomers, fibrils, and plaques, are thought to exert toxic effects on neurons and synapses, disrupt cell function, and lead to synaptic dysfunction and loss.
