Segment from a 4-minute animation that explores the pathophysiology of sickle cell disease and the progressive, tissue-damaging effects of chronic hemolysis and anemia.
Our assignment: visually depict several key critical aspects of the SCD story, such as hemoglobin S (HbS) polymerization, red blood cell sickling and tethering, vaso-occlusion, and chronic hemolysis.
Sickled red blood cells promote inflammation, obstruct the vasculature, injure the endothelium, and may lead to ischemic damage in vital organs.
