A few frames from animation that depicts the progression of diabetic nephropathy, a driver of chronic kidney disease in people with diabetes.
Here in the glomerulus, the images show progressive damage to the tubules, damage to podocytes (including loss of them), and scarring as a result of mesangial cells excreting extracellular matrix.
The last image depicts contracted, granular kidneys from long-term hypertension.
Animation was created for client’s episode on chronic kidney disease and the relationship between type 2 diabetes and cardiovascular risk in patients with advanced CKD.