Fat cell enlargement in obesity is related to insulin resistance and type 2 diabetes.
In this sequence, we travel into the visceral fat and see an active environment – teeming with overstressed, damaged fat cells, vasculature, and immune cells.
Stress on these hypertrophic adipocytes results in lipid spillover (fatty acid release) into the circulation, as well as proinflammatory cytokine release and immune cell recruitment.
