CAR T-cell animation

A CAR T-cell therapy targeting B-cell maturation antigen (BCMA)

Apr 21, 2022

A few selected segments from a 6-minute animation created for a first-in-class B-cell maturation antigen (BCMA)-directed personalized immunotherapy called chimeric antigen receptor (CAR) T-cell therapy.

In this CAR T therapy, the T cells are engineered to target a protein called BCMA, which is found in abundance on multiple myeloma cells, but is absent from nearly all normal cells.

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Fat cell enlargement & type 2 diabetes

Apr 22, 2022

Fat cell enlargement in obesity is related to insulin resistance and type 2 diabetes.

In this sequence, we travel into the visceral fat and see an active environment – teeming with overstressed, damaged fat cells, vasculature, and immune cells.

Stress on these hypertrophic adipocytes results in lipid spillover (fatty acid release) into the circulation, as well as proinflammatory cytokine release and immune cell recruitment.

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